Teaching Points
Reveal the molecular relationship between structure and function, protein synthesis, and mutation as you tell classic stories in biology. Oxygen transport and how it can be disrupted becomes real in your students’ hands as they:
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- Interpret folding maps to form the primary structure of the protein with mini toobers
- Fold 3 mini toobers into alpha helices and then their tertiary structures
- Assemble the three fragments together to form ß-globin
- Add the heme group with an iron atom and O2
You can create an authentic application activity as students predict the impact of a single-point mutation on the function of the protein. This kit is most effective after students have explored the Amino Acid Starter Kit©.
Find additional resources for this kit here: ß-Globin Folding Kit© Classroom Resources
